Comparative Study
doi: 10.1016/0014-5793(89)81396-1.
Adenine nucleotides regulate Ca2+ transport in brain mitochondria
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- PMID: 2497035
- DOI: 10.1016/0014-5793(89)81396-1
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Comparative Study
Adenine nucleotides regulate Ca2+ transport in brain mitochondria
FEBS Lett.
.
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Abstract
Adenine nucleotides (ADP greater than ATP) greatly enhance Ca2+ uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca2+ down to cellular free Ca2+ levels, suggesting a role for mitochondria in modulating Ca2+ cycles in brain cells. Analysis of the effects of various inhibitors on Ca2+ uptake and efflux suggest that locking the ADP/ATP translocator in its M-state stimulates electrogenic Ca2+ uptake and, to a lesser extent, inhibits Ca2+ efflux. It is suggested that this effect is due to a modulation of the surface charge on the M-side which enhances Ca2+ dissociation from the carriers.
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