Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 26;2(3):e00541-14.
doi: 10.1128/genomeA.00541-14.

Genome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D

Juan D Rojas  1 , Antonio Starcevic  2 , Damir Baranas̆ić  2 , Maria A Ferreira-Torres  1 , Camilo A Contreras  1 , Leandro M Garrido  1 , Welington L Araújo  1 , Robson F de Souza  1 , Jurica Zucko  2 , Daslav Hranueli  2 , Paul F Long, John Cullum  3 , Gabriel Padilla  4
Affiliations

Genome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D

Juan D Rojas et al. Genome Announc. .

Abstract

Streptomyces olindensis DAUFPE 5622, which was isolated from a Brazilian soil sample, produces the antitumor anthracycline cosmomycin D. The genome sequence is 9.4 Mb in length, with a G+C content of 71%. Thirty-four putative secondary metabolite biosynthetic gene clusters were identified, including the cosmomycin D cluster.

PubMed Disclaimer

References

    1. Garrido LM, Lombó F, Baig I, Nur-e-Alam M, Furlan RL, Borda CC, Braña A, Méndez C, Salas JA, Rohr J, Padilla G. 2006. Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes. Appl. Microbiol. Biotechnol. 73:122–131. 10.1007/s00253-006-0453-z - DOI - PMC - PubMed
    1. Furlan RL, Watt SJ, Garrido LM, Amarante-Mendes GP, Nur-e-Alam M, Rohr J, Braña A, Mendez C, Salas JA, Sheil MM, Beck JL, Padilla G. 2004. DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains. J. Antibiot. 57:647–654. 10.7164/antibiotics.57.647 - DOI - PubMed
    1. Carvalho H, Garrido LM, Furlan RL, Padilla G, Agnoletto M, Guecheva T, Henriques JA, Saffi J, Menck CF. 2010. DNA damage induced by the anthracycline cosmomycin D in DNA repair-deficient cells. Cancer Chemother. Pharmacol. 65:989–994. 10.1007/s00280-010-1244-x - DOI - PubMed
    1. Walsh C, Fischbach M. 2010. Natural products version 2.0: connecting genes to molecules. J. Am. Chem. Soc. 132:2469–2493. 10.1021/ja909118a - DOI - PMC - PubMed
    1. Chen CW, Yu TW, Lin YS, Kieser HM, Hopwood DA. 1993. The conjugative plasmid SLP2 of Streptomyces lividans is a 50 kb linear molecule. Mol. Microbiol. 7:925–932. 10.1111/j.1365-2958.1993.tb01183.x - DOI - PubMed

LinkOut - more resources