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. 2014 Jun 12:5:290.
doi: 10.3389/fmicb.2014.00290. eCollection 2014.

Siderophores as "Trojan Horses": tackling multidrug resistance?

Carla C C R de Carvalho  1 , Pedro Fernandes  2
Affiliations

Siderophores as "Trojan Horses": tackling multidrug resistance?

Carla C C R de Carvalho et al. Front Microbiol. .
No abstract available

Keywords: anti-bacterial acitivity; drug delivery; iron transport; multidrug resistance; siderophore conjugates.

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Figures

Figure 1
Figure 1
Schematic of the “Trojan horse” strategy in Gram-negative bacteria. Antibiotic bound-siderophores bind to outer-memberane receptors which help their transport to the periplasmic space upon interaction with the Ton complex. In the periplasm, siderophores are sequestered by periplasmic-binding proteins which deliver them to ATP-dependent transporters which help their entrance into the cell. Antibiotics which would not pass cellular membranes otherwise, can therefore be released.
See this image and copyright information in PMC

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