Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women
- PMID: 24971105
- PMCID: PMC4064771
Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women
Abstract
Objective: To compare the hormonal status in postmenopausal women with and without metabolic syndrome.
Materials and methods: In this cross sectional study 110 postmenopausal women were enrolled. Participants completed a questionnaire and underwent a medical exam and serum evaluation for serum lipids including cholesterol (Chol), high density lipoprotein cholesterol (HDL), low density lipoprotein (LDL), triglyceride (TG), fasting blood sugar (FBS), sex hormone binding globulin (SHBG), estradiol and testosterone. Metabolic syndrome was defined according to the definition of the National Cholesterol Education Program- Adult Treatment Panel III. In this study P value less than 0.05 was accepted as significant.
Results: There were significant differences between the two groups of participants with and without metabolic syndrome in age, years after menopause, BMI, weight, SHBG and testosterone (p< 0.01).
Conclusion: SHBG and testosterone are the most significant correlated factors to metabolic syndrome in postmenopausal women.
Keywords: hormonal status; metabolic syndrome; postmenopausal women.
Similar articles
-
Relationship between reproductive aging, body composition, hormonal status and metabolic syndrome in postmenopausal women.Climacteric. 2011 Dec;14(6):649-53. doi: 10.3109/13697137.2011.570386. Epub 2011 Sep 26. Climacteric. 2011. PMID: 21942693
-
Determinants of sex hormone-binding globulin blood concentrations in premenopausal and postmenopausal women with different estrogen status. Virgilio-Menopause-Health Group.Metabolism. 1997 Jan;46(1):5-9. doi: 10.1016/s0026-0495(97)90159-1. Metabolism. 1997. PMID: 9005961
-
Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women.Metabolism. 2006 Nov;55(11):1473-80. doi: 10.1016/j.metabol.2006.06.017. Metabolism. 2006. PMID: 17046549 Free PMC article.
-
[Clinical features, hormonal profile, and metabolic abnormalities of obese women with obese polycystic ovary syndrome].Zhonghua Yi Xue Za Zhi. 2005 Dec 7;85(46):3266-71. Zhonghua Yi Xue Za Zhi. 2005. PMID: 16409817 Chinese.
-
Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk.J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):567-72. doi: 10.1016/0960-0760(95)00102-6. J Steroid Biochem Mol Biol. 1995. PMID: 7626511 Review.
Cited by
-
Sex Hormone Regulation of Proteins Modulating Mitochondrial Metabolism, Dynamics and Inter-Organellar Cross Talk in Cardiovascular Disease.Front Cell Dev Biol. 2021 Feb 11;8:610516. doi: 10.3389/fcell.2020.610516. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33644031 Free PMC article. Review.
-
Metabolic syndrome and body shape predict differences in health parameters in farm working women.BMC Public Health. 2018 Apr 4;18(1):453. doi: 10.1186/s12889-018-5378-9. BMC Public Health. 2018. PMID: 29618342 Free PMC article.
-
Associations of visceral fat area and physical activity levels with the risk of metabolic syndrome in postmenopausal women.Biogerontology. 2017 Jun;18(3):357-366. doi: 10.1007/s10522-017-9693-9. Epub 2017 Mar 18. Biogerontology. 2017. PMID: 28316012 Free PMC article.
-
Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome.Sci Rep. 2021 Mar 4;11(1):5175. doi: 10.1038/s41598-021-84301-x. Sci Rep. 2021. PMID: 33664334 Free PMC article.
-
Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity.Int J Mol Sci. 2022 Oct 21;23(20):12680. doi: 10.3390/ijms232012680. Int J Mol Sci. 2022. PMID: 36293536 Free PMC article.
References
-
- Cameron A. The metabolic syndrome: Validity and utility of clinical definitions for cardiovascular disease and diabetes risk prediction. Maturitas. 2010;65:117–21. - PubMed
-
- Ding QF, Hayashi T, Zhang XJ, Funami J, Ge L, Li J, Huang XL, et al. Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopusal women. Journal of Diabetes and Its Complications. 2007;21:315–19. - PubMed
-
- Martínez MA, Puig JG, Mora M, Aragón R, O'Dogherty P, Antón JL, et al. Metabolic syndrome: prevalence, associated factors, and C- reactive protein. The MADRIC ( MADrid RIesgo Cardiovascular) Study. Metabolism clinical and Exprimental. 2008;57:1232–40. - PubMed
-
- Gaspard U. Hyperinsulinaemia, a key factor of The metabolic syndrome in postmenopausal women. Maturitas. 2009;62:362–5. - PubMed
-
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults(Adult Treatment Panel III) JAMA. 2003;285:2486–97. - PubMed
LinkOut - more resources
Full Text Sources
Miscellaneous