Caffeic acid phenethyl ester and therapeutic potentials
- PMID: 24971312
- PMCID: PMC4058104
- DOI: 10.1155/2014/145342
Caffeic acid phenethyl ester and therapeutic potentials
Abstract
Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.
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References
-
- Metzner J, Beckemeier H, Paintz M, Schneidewind E. Zur antimikrobieller Wirksamkeit von Porpolis und Propolisinhaltstoffen. Pharmazie. 1979;34:97–102. - PubMed
-
- Bankova V. Chemical diversity of propolis makes it a valuable source of new biologically active compounds. Journal of ApiProduct and ApiMedical Science. 2009;1:23–28.
-
- Kumazawa S, Ahn M-R, Fujimoto T, Kato M. Radical-scavenging activity and phenolic constituents of propolis from different regions of Argentina. Natural Product Research. 2010;24(9):804–812. - PubMed
-
- Grunberger D, Banerjee R, Eisinger K, et al. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia. 1988;44(3):230–232. - PubMed
-
- Chen H-C, Chen J-H, Chang C, Shieh C-J. Optimization of ultrasound-accelerated synthesis of enzymatic caffeic acid phenethyl ester by response surface methodology. Ultrasonics Sonochemistry. 2011;18(1):455–459. - PubMed
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