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. 2014:2014:492872.
doi: 10.1155/2014/492872. Epub 2014 May 26.

Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis

Xu Wang  1 , Lihua Zhu  2 , Ziwei Liao  3 , Fan Zhang  3 , Ling Xu  3 , Yan Xu  1 , Shaohua Chen  3 , Lijian Yang  3 , Yi Zhou  4 , Yangqiu Li  5
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Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis

Xu Wang et al. J Immunol Res. 2014.

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the expression level of A20, NF-κB, and A20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) in patients with RA. Real-time PCR was used to determine the expression level of MALT1, MALT-V1, A20, and NF-κB genes in RA and healthy individuals (HI). Significantly lower A20 expression was found in RA patients compared with those in the healthy group, while NF-κB overexpression could be detected in patients with RA. Moreover, the MALT1 and MALT1-V1 expression level was downregulated in RA patients. A positive correlation between MALT1 and A20 and MALT1-V1 and A20 was found in patients with RA, and a tendency towards a negative correlation was found between MALT1 and NF-κB, MALT1-V1 and NF-κB, and A20 and NF-κB. In conclusion, we first characterized the alternative expression pattern of MALT1, A20, and NF-κB in RA, which may be related to abnormal T cell activation.

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Figures

Figure 1
Figure 1
The expression level of A20 and NF-κB in patients with RA and healthy individuals.
Figure 2
Figure 2
The expression level of MALT1-V1 and total MALT1 in patients with RA and healthy individuals.
Figure 3
Figure 3
Correlation between the gene expression levels of MALT1 and A20 (a) and MALT1-V1 and A20 (b) in patients with RA.
See this image and copyright information in PMC

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References

    1. Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell. 1996;85(3):307–310. - PubMed
    1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356–361. - PubMed
    1. Vinay DS, Kwon BS. Targeting TNF superfamily members for therapeutic intervention in rheumatoid arthritis. Cytokine. 2012;57(3):305–312. - PubMed
    1. Cooles FA, Isaacs JD. Pathophysiology of rheumatoid arthritis. Current Opinion in Rheumatology. 2011;23(3):233–240. - PubMed
    1. Campbell IK, Gerondakis S, O’Donnell K, Wicks IP. Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis. Journal of Clinical Investigation. 2000;105(12):1799–1806. - PMC - PubMed

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