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. 1989 May 1;169(5):1859-64.
doi: 10.1084/jem.169.5.1859.

Murine V kappa gene expression does not follow the VH paradigm

A Kaushik  1 , D H Schulze, C Bona, G Kelsoe
Affiliations

Murine V kappa gene expression does not follow the VH paradigm

A Kaushik et al. J Exp Med. .

Abstract

V kappa gene family expression among LPS-reactive murine B lymphocytes, unlike that of VH gene families, is not proportional to genomic complexity, i.e., nonstoichiometric. Furthermore, no positional bias for the overexpression of J-proximal V kappa genes (V kappa 21) is observed among neonatal B lymphocytes. Yet, the V kappa 1 and V kappa 9 families located in the center of V kappa locus are preferentially used by neonatal B splenocytes. Thus, the mechanisms of V kappa gene rearrangement and expression appear to differ significantly from those controlling the VH locus.

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