Role of gonadotropin releasing hormone agonists in ovulation induction
- PMID: 2497247
Role of gonadotropin releasing hormone agonists in ovulation induction
Abstract
The use of exogenous gonadotropins for ovulation induction in anovulatory women or for superovulation in gamete intrafallopian transfer or in vitro fertilization is complicated by premature luteinization, multiple gestation and ovarian hyperstimulation. Desensitization of the pituitary gonadotrophs can be achieved with gonadotropin releasing hormone (GnRH) agonists. The adjunctive use of GnRH agonists with exogenous gonadotropins prevents premature luteinization, possibly resulting in an improvement in ovarian stimulation.
Similar articles
-
Adjunctive leuprolide therapy does not improve cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination of subfertile women.Obstet Gynecol. 1991 Aug;78(2):187-90. Obstet Gynecol. 1991. PMID: 1906152 Clinical Trial.
-
[The use of pulsatile gonadotropins and gonadotropin releasing hormone analogues for ovulation induction in chronic anovulatory patients].Minerva Ginecol. 1988 Aug;40(8):457-60. Minerva Ginecol. 1988. PMID: 3063999 Italian. No abstract available.
-
Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer.Gynecol Endocrinol. 2006 May;22(5):235-8. doi: 10.1080/14767050600761893. Gynecol Endocrinol. 2006. PMID: 16785142 Clinical Trial.
-
Ovulation stimulation and induction.Endocrinol Metab Clin North Am. 1992 Mar;21(1):57-84. Endocrinol Metab Clin North Am. 1992. PMID: 1576983 Review.
-
Advances in induction of ovulation.Curr Opin Obstet Gynecol. 1994 Apr;6(2):136-40. Curr Opin Obstet Gynecol. 1994. PMID: 8193252 Review.
Cited by
-
Luteinizing response to human chorionic gonadotropin does not predict outcome in gonadotropin releasing hormone agonist-suppressed/human menopausal gonadotropin-stimulated in vitro fertilization (IVF) cycles.J Assist Reprod Genet. 1992 Jun;9(3):244-7. doi: 10.1007/BF01203821. J Assist Reprod Genet. 1992. PMID: 1525454
-
LH suppression following different low doses of the GnRH antagonist ganirelix in polycystic ovary syndrome.J Endocrinol Invest. 2005 Dec;28(11):990-7. doi: 10.1007/BF03345337. J Endocrinol Invest. 2005. PMID: 16483177 Clinical Trial.
-
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques.Cochrane Database Syst Rev. 2017 May 25;5(5):CD006109. doi: 10.1002/14651858.CD006109.pub3. Cochrane Database Syst Rev. 2017. PMID: 28540977 Free PMC article.