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Randomized Controlled Trial
. 2014 Jun 28:13:67.
doi: 10.1186/1475-2891-13-67.

A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial

Hideki Nakayama  1 , Nobuaki Tsuge, Hiroshi Sawada, Noriya Masamura, Shohei Yamada, Shigeki Satomi, Yukihito Higashi
Affiliations
Randomized Controlled Trial

A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial

Hideki Nakayama et al. Nutr J. .

Abstract

Background: Curry, one of the most popular foods in Japan, contains spices that are rich in potentially antioxidative compounds, such as curcumin and eugenol. Oxidative stress is thought to impair endothelial function associated with atherosclerosis, a leading cause of cardiovascular events. The aim of this study was to determine whether a single consumption of curry meal would improve endothelial function in healthy men.

Methods: Fourteen healthy male subjects (BMI 23.7 ± 2.7 kg/m2; age 45 ± 9 years) were given a single serving of curry meal or spice-free control meal (180 g of curry or control and 200 g of cooked rice; approximately 500 kcal in total) in a randomized, controlled crossover design. Before and 1 hr after the consumption, fasting and postprandial flow-mediated vasodilation (FMD) responses and other parameters were measured.

Results: The consumption of the control meal decreased FMD from 5.8 ± 2.4% to 5.1 ± 2.3% (P = 0.039). On the other hand, the consumption of the curry meal increased FMD from 5.2 ± 2.5% to 6.6 ± 2.0% (P = 0.001), and the postprandial FMD after the curry meal was higher than that after the control meal (P = 0.002). Presence of spices in the curry did not alter significantly the systemic and forearm hemodynamics, or any biochemical parameters including oxidative stress markers measured.

Conclusions: These findings suggest that the consumption of curry ameliorates postprandial endothelial function in healthy male subjects and may be beneficial for improving cardiovascular health.

Trial registration: UMIN Clinical Trials Registry 000012012.

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Figures

Figure 1
Figure 1
Effects of a single consumption of curry on flow-mediated vasodilation (FMD), n = 14. Because the interaction between meals (control/curry) and prandial status (fasting/postprandial) was found significant (P = 0.002) by using two-way within subjects ANOVA, P values were calculated by post hoc Student’s paired t-test. Abbreviations: FMD flow-mediated vasodilation.
See this image and copyright information in PMC

References

    1. Sen CT. Curry: A Global History. London: Reaktion Books; 2009.
    1. Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med. 2010;10:57. - PMC - PubMed
    1. Esatbeyoglu T, Huebbe P, Ernst IMA, Chin D, Wagner AE, Rimbach G. Curcumin–from molecule to biological function. Angew Chem Int Ed. 2012;51:5308–5332. - PubMed
    1. Damiani CEN, Rossoni LV, Vassallo DV. Vasorelaxant effects of eugenol on rat thoracic aorta. Vascul Pharmacol. 2003;40:59–66. - PubMed
    1. Zin WA, Silva AGLS, Magalhaes CB, Carvalho GMC, Riva DR, Lima CC, Leal-Cardoso JH, Takiya CM, Valenca SS, Saldiva PHN, Faffe DS. Eugenol attenuates pulmonary damage induced by diesel exhaust particles. J Appl Physiol. 2011;112:911–917. - PubMed

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