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Review
. 2015 Feb;48(1):25-35.
doi: 10.1007/s12020-014-0327-6. Epub 2014 Jun 28.

GH and the cardiovascular system: an update on a topic at heart

Jörgen Isgaard  1 , Michele Arcopinto, Kristjan Karason, Antonio Cittadini
Affiliations
Review

GH and the cardiovascular system: an update on a topic at heart

Jörgen Isgaard et al. Endocrine. 2015 Feb.

Abstract

In this review, the importance of growth hormone (GH) for the maintenance of normal cardiac function in adult life is discussed. Physiological effects of GH and underlying mechanisms for interactions between GH and insulin-like growth factor I (IGF-I) and the cardiovascular system are covered as well as the cardiac dysfunction caused both by GH excess (acromegaly) and by GH deficiency in adult hypopituitary patients. In both acromegaly and adult GH deficiency, there is also increased cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Finally, the status of the GH/IGF-I system in relation to heart failure and the potential of GH as a therapeutic tool in the treatment of heart failure are reviewed in this article.

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