Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 28:20:1090-4.
doi: 10.12659/MSM.890460.

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

Oguz Idiz  1 , Erhan Aysan  1 , Deniz Firat  2 , Yeliz Emine Ersoy  1 , Merve Busra Cengiz  1 , Huseyin Akbulut  1 , Arda Isık  2 , Mahmut Muslumanoglu  1
Affiliations

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

Oguz Idiz et al. Med Sci Monit. .

Abstract

Background: We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.

Material and methods: We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.

Results: The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).

Conclusions: Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histopathological view of minimal fibrosis at grade-1 level adhesion (example from glycerol group).
Figure 2
Figure 2
Histopathological view of modarate level fibrosis at grade 2 level adhesion (example from flax-oil group).
Figure 3
Figure 3
Histopathological view of advanced fibrosis at grade 3 level adhesion (example from control group).
See this image and copyright information in PMC

References

    1. Herrick EH, Mutsaers SE, Ozua P, et al. Human peritoneal adhesions are highly cellular, innervated and vascularized. J Pathol. 2000;192:67–72. - PubMed
    1. Hellebrekers BWJ, Trimbos-Kemper TCM, Trimbos JBMZ, et al. Use of fibrinolytic agents in the prevention of postoperative adhesion formation. Fertil Steril. 2000;74:203–12. - PubMed
    1. Senthilkumar MP, Dreyer JS. Peritoneal adhesions: pathogenesis, assessment and effects. Trop Gastroenterol. 2006;27:11–18. - PubMed
    1. Hershalg A, Diamond MP, DeCherney AH. Adhesiolysis. Clin Obstet Gynecol. 1991;34:395–98. - PubMed
    1. Canbaz MA, Ustun C, Kocak D, Yanık FF. The comparsion of gonadotropinreleasing hormone agonist therapy and intraperitoneal Ringer’s lactate solution in prevention of postopertive adhesion formation in rat medels. Obstet Gynecol. 1999;82:219–22. - PubMed