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. 2014 Sep:66:267-76.
doi: 10.1016/j.bone.2014.06.021. Epub 2014 Jun 25.

MiR-126-5p regulates osteolysis formation and stromal cell proliferation in giant cell tumor through inhibition of PTHrP

Wang Zhou  1 , Huabin Yin  1 , Ting Wang  1 , Tielong Liu  1 , Zhenxi Li  1 , Wangjun Yan  1 , Dianwen Song  1 , Haiyan Chen  2 , Jia Chen  1 , Wei Xu  1 , Xinghai Yang  3 , Zhipeng Wu  4 , Jianru Xiao  5
Affiliations

MiR-126-5p regulates osteolysis formation and stromal cell proliferation in giant cell tumor through inhibition of PTHrP

Wang Zhou et al. Bone. 2014 Sep.

Abstract

Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). MiR-126-5p is an intronic miRNA identified as tumor suppressor in many tumors, but its role in GCT is poorly understood. We found that miR-126-5p was decreased in GCT and could directly regulate PTHrP expression. Furthermore, miR-126-5p could control osteoclast (OC) differentiation, GCTSC proliferation and osteolysis formation in GCT through negative regulation of PTHrP. Thus, these results suggest that miR-126-5p could directly target PTHrP and have a tumor suppressor function in GCT.

Keywords: Giant cell tumor; Osteoclast differentiation; Osteolysis; PTHrP; miR-126-5p.

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