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Review
. 1989 Jan;6(1):1-3.
doi: 10.1023/a:1015848515036.

Benzodiazepines: are they of natural origin?

E Unseld  1 , U Klotz
Affiliations
Review

Benzodiazepines: are they of natural origin?

E Unseld et al. Pharm Res. 1989 Jan.

Abstract

Three research groups have provided evidence that benzodiazepines might be also of natural origin. In the brain of different species including humans and in several plant products, desmethyldiazepam and diazepam are detectable by immunological methods and gas chromatography--mass spectrometry. Thus, benzodiazepines represent natural drugs which may be incorporated into animals and humans through plant products. Whether the measured low concentrations (ranging from 0.01 up to 600 ng/g wet weight) have any biological role or clinical significance remains to be determined.

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References

    1. J Am Chem Soc. 1965 Dec 20;87(24):5793-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Dec;83(24):9784-8 - PubMed
    1. Biochim Biophys Acta. 1967 Jul 25;141(2):266-9 - PubMed
    1. Biochem Pharmacol. 1988 Oct 1;37(19):3549-59 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5560-4 - PubMed

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