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. 1989;97(3):424-6.
doi: 10.1007/BF00439464.

Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety

H A Baldwin  1 , S E File
Affiliations

Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety

H A Baldwin et al. Psychopharmacology (Berl). 1989.

Abstract

Rats were chronically treated with chlordiazepoxide (CDP 10 mg/kg/day) or vehicle for 27 days. Twenty-four hours after their last dose, they received flumazenil (4 mg/kg) or vehicle and were tested in the social interaction test, in a low-light, familiar arena. CDP withdrawal significantly reduced the time spent in social interaction compared with controls, indicating an anxiogenic withdrawal response. This was completely reversed by flumazenil. A second group received CDP for 27 days and, in addition, received a single dose of flumazenil (4 mg/kg) 6 days before testing. Flumazenil prevented the development of the anxiogenic withdrawal response in these rats.

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