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Editorial
. 2015 Jan;61(1):15-7.
doi: 10.1002/hep.27279. Epub 2014 Nov 20.

Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis

Petra Hirsova  1 , Gregory J Gores
Affiliations
Editorial

Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis

Petra Hirsova et al. Hepatology. 2015 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic overview of hedgehog pathway activation in NASH. Simplified illustration demonstrates that JNK activation by toxic lipids leads to Shh production in ballooned hepatocytes. Released Shh acts via autocrine pathway as a survival factor for “undead” ballooned hepatocytes and via paracrine mechanism induces fibroblast differentiation into extracellular matrix-producing myofibroblasts. Vitamin E therapy decreases amount of Shh in NASH liver by unknown mechanism. JNK, c-Jun-N-terminal kinase; Shh, sonic hedgehog.
See this image and copyright information in PMC

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References

    1. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003;125:437–443. - PubMed
    1. Ribeiro PS, Cortez-Pinto H, Sola S, Castro RE, Ramalho RM, Baptista A, Moura MC, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol. 2004;99:1708–1717. - PubMed
    1. Guy CD, Suzuki A, Zdanowicz M, Abdelmalek MF, Burchette J, Unalp A, Diehl AM. Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology. 2012;55:1711–1721. - PMC - PubMed
    1. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321. - PubMed
    1. Bohinc BN, Diehl AM. Mechanisms of disease progression in NASH: new paradigms. Clin Liver Dis. 2012;16:549–565. - PubMed