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Review
. 2014 Nov 12;32(48):6377-89.
doi: 10.1016/j.vaccine.2014.06.065. Epub 2014 Jun 24.

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

Julia Scheiermann  1 , Dennis M Klinman  2
Affiliations
Review

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

Julia Scheiermann et al. Vaccine. .

Abstract

Synthetic oligonucleotides (ODN) that express unmethylated "CpG motifs" trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer.

Keywords: Adjuvant; Cancer; CpG olignucleotide; Infection; Toll-like receptor.

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Conflict of interest statement

Conflict of interest

Dr. Klinman and members of his lab have patents related to the use of CpG ODN. All rights to such patents have been assigned to the Federal Government.

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