Review
doi: 10.1016/j.hfc.2014.04.002.
Epub 2014 May 22.
Causes and pathophysiology of heart failure with preserved ejection fraction
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- PMID: 24975903
- DOI: 10.1016/j.hfc.2014.04.002
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Review
Causes and pathophysiology of heart failure with preserved ejection fraction
Heart Fail Clin.
2014 Jul.
Abstract
Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent and gender-dependent hemodynamic alterations of diastolic ventricular function.
Keywords: Comorbidities; Exercise intolerance; Heart failure with preserved ejection fraction; Myocardial stiffness; Ventricular-arterial uncoupling.
Copyright © 2014 Elsevier Inc. All rights reserved.
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