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Review
. 2014 Jul;10(3):445-52.
doi: 10.1016/j.hfc.2014.04.001. Epub 2014 May 22.

Exercise physiology in heart failure and preserved ejection fraction

Mark J Haykowsky  1 , Dalane W Kitzman  2
Affiliations
Review

Exercise physiology in heart failure and preserved ejection fraction

Mark J Haykowsky et al. Heart Fail Clin. 2014 Jul.

Abstract

Recent advances in the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFPEF) suggest that noncardiac peripheral factors contribute to the reduced peak V(o2) (peak exercise oxygen uptake) and to its improvement after endurance exercise training. A greater understanding of the peripheral skeletal muscle vascular adaptations that occur with physical conditioning may allow for tailored exercise rehabilitation programs. The identification of specific mechanisms that improve whole body and peripheral skeletal muscle oxygen uptake could establish potential therapeutic targets for medical therapies and a means to follow therapeutic response.

Keywords: Exercise physiology; Heart failure and preserved ejection fraction; Physical conditioning.

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Figures

Figure 1
Figure 1
Peak oxygen uptake in HFFEF patients. Data from Refs ,,,.
Figure 2
Figure 2
Determinants of exercise intolerance in HFPEF patients. ATP, adenosine triphosphate; RV, right ventricle; LV, left ventricle; O2, oxygen.
See this image and copyright information in PMC

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