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Review
. 2014 May-Jun;20(3):275-82.
doi: 10.15274/INR-2014-10033. Epub 2014 Jun 17.

MR-guided focused ultrasound: a new generation treatment of Parkinson's disease, essential tremor and neuropathic pain

Pawel Piotr Dobrakowski  1 , Agnieszka Kamila Machowska-Majchrzak  2 , Beata Labuz-Roszak  2 , Krzysztof Grzegorz Majchrzak  2 , Ewa Kluczewska  2 , Krystyna Barbara Pierzchała  2
Affiliations
Review

MR-guided focused ultrasound: a new generation treatment of Parkinson's disease, essential tremor and neuropathic pain

Pawel Piotr Dobrakowski et al. Interv Neuroradiol. 2014 May-Jun.

Abstract

The application of high intense focused ultrasound (HIFU) is currently the subject of many experimental and clinical trials. The combination of HIFU with MRI guidance known as MR-guided focused ultrasound (MRgFUS) appears to be particularly promising to ablate tissues located deep in the brain. The method can be the beginning of interventional neurology and an important alternative to neurosurgery. Studies conducted to date show the effectiveness of the method both in chronic diseases and in emergency cases. The safety and effectiveness of this method have been observed in parkinsonian and essential tremor as well as in neuropathic pain. The procedure does not require anaesthesia. Ionizing radiation is not used and there is no risk of cumulative dose. Such advantages may result in low complication rates and medical justification for further development of MRgFUS.

Keywords: MR-guided focused ultrasound; essential tremor; neuropathic pain; parkinsonian tremor.

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References

    1. Moser D, Zadicario E, Schiff G, et al. Measurement of targeting accuracy in focused ultrasound functional neurosurgery. Neurosurg Focus. 2012;32(1):E2. doi: 10.3171/2011.10.FOCUS11246. - DOI - PubMed
    1. Hariharan P, Myers MR, Banerjee RK. HIFU procedures at moderate intensities-effect of large blood vessel. Phys. Med. Biol. 2007;52:3493–3513. doi: 10.1088/0031-9155/52/12/011. - DOI - PubMed
    1. Sapareto SA, Dewey WC. Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys. 1984;10(6):787–800. doi: 10.1016/0360-3016(84)90379-1. - DOI - PubMed
    1. Corbett RJ, aptook AR, Tollefsbol G, et al. Validation of a noninvasive method to measure brain temperature in vivo using 1H NMR spectroscopy. J Neurochem. 1995;64(3):1224–1230. doi: 10.1046/j.1471-4159.1995.64031224.x. - DOI - PubMed
    1. Corbett R, Laptook AR, Weatherall P. Noninvasive measurements of human brain temperature using volume-localized proton magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 1997;17(4):363–369. doi: 10.1097/00004647-199704000-00001. - DOI - PubMed

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