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Review
. 2014 Aug:28:165-70.
doi: 10.1016/j.copbio.2014.05.007. Epub 2014 Jun 27.

Systems analysis and the prediction and prevention of Type 2 diabetes mellitus

Richard N Bergman  1 , Darko Stefanovski  2 , Stella P Kim  2
Affiliations
Review

Systems analysis and the prediction and prevention of Type 2 diabetes mellitus

Richard N Bergman et al. Curr Opin Biotechnol. 2014 Aug.

Abstract

Prevalence of Type 2 diabetes has increased at an alarming rate, highlighting the need to correctly predict the development of this disease in order to allow intervention and thus, slow progression of the disease and resulting metabolic derangement. There have been many recent 'advances' geared toward the detection of pre-diabetes, including genome wide association studies and metabolomics. Although these approaches generate a large amount of data with a single blood sample, studies have indicated limited success using genetic and metabolomics information alone for identification of disease risk. Clinical assessment of the disposition index (DI), based on the hyperbolic law of glucose tolerance, is a powerful predictor of Type 2 diabetes, but is not easily assessed in the clinical setting. Thus, it is evident that combining genetic or metabolomic approaches for a more simple assessment of DI may provide a useful tool to identify those at highest risk for Type 2 diabetes, allowing for intervention and prevention.

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Figures

Figure 1
Figure 1
Cumulative incidence rates of type 2 diabetes in women with previous gestational diabetes who were treated with either placebo or troglitazone. The rate in the troglitazone group was significantly lower than the rate in the placebo group (P = 0.009). From [9].
Figure 2
Figure 2
Ethnic differences in the relationship between insulin sensitivity and insulin response. From [26]
Figure 3
Figure 3
Changes in insulin response relative to changes in insulin sensitivity in Pima Indian subjects. Those with a higher DI retained normal glucose tolerance (NGT) (nonprogressors) whereas those with a lower DI deteriorated from NGT to impaired (IGT) to diabetic (DIA) (progressors). From [32].
See this image and copyright information in PMC

References

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