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Review
. 2014 Jun 26;6(6):376-80.
doi: 10.4330/wjc.v6.i6.376.

Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism

Fulvia Gloria-Bottini  1 , Patrizia Saccucci  1 , Maria Banci  1 , Paolo Nardi  1 , Mattia Scognamiglio  1 , Antonio Pellegrino  1 , Egidio Bottini  1 , Luigi Chiariello  1
Affiliations
Review

Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism

Fulvia Gloria-Bottini et al. World J Cardiol. .

Abstract

PTPN22 has been previously found associated with coronary artery disease (CAD). In the present note we have studied the effect of p53 codon 72, acid phosphatse locus 1 (ACP1) and adenosine deaminase (ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD, 122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular disease without CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1, p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders.

Keywords: Acid phosphatse locus 1; Adenosine deaminase 2; Coronary artery disease; PTPN22; p53 codon 72.

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Figures

Figure 1
Figure 1
Twenty-two non diabetic subjects with coronary artery disease had no factor contributing to increase the proportion of *T carriers, 54 subjects had 1 factor, 46 had 2 factors and 6 had 3 factors.
Figure 2
Figure 2
Twenty-three non diabetic subjects with cardiovascular diseases without coronary artery disease had no factor contributing to increase the proportion of *T carriers, 52 subjects had 1 factor, 27 had 2 factors and 15 had 3 factors.
See this image and copyright information in PMC

References

    1. Saccucci P, Banci M, Cozzoli E, Neri A, Magrini A, Bottini E, Gloria-Bottini F. Atherosclerosis and PTPN22: a study in coronary artery disease. Cardiology. 2011;119:54–56. - PubMed
    1. Pertovaara M, Kähönen M, Juonala M, Laitinen T, Taittonen L, Lehtimäki T, Viikari JS, Raitakari OT, Hurme M. Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study. Rheumatology (Oxford) 2009;48:1553–1556. - PubMed
    1. Zheng SJ, Lamhamedi-Cherradi SE, Wang P, Xu L, Chen YH. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes. 2005;54:1423–1428. - PubMed
    1. Jailwala P, Waukau J, Glisic S, Jana S, Ehlenbach S, Hessner M, Alemzadeh R, Matsuyama S, Laud P, Wang X, et al. Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation. PLoS One. 2009;4:e6527. - PMC - PubMed
    1. Saccucci P, Banci M, Amante A, Bottini E, Gloria-Bottini F. Coronary artery disease: evidence of interaction between PTPN22 and p53 genetic polymorphisms. Cardiology. 2011;120:166–168. - PubMed