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. 2014 Jul 1;1(5):468-472.
doi: 10.1039/C4QO00057A.

Vanadium-Catalyzed C(sp3)-H Fluorination Reactions

Ji-Bao Xia, Yuyong Ma, Chuo Chen

Vanadium-Catalyzed C(sp3)-H Fluorination Reactions

Ji-Bao Xia et al. Org Chem Front. .

Abstract

Vanadium(III) oxide catalyzes the direct fluorination of C(sp3)-H groups with Selectfluor. This reaction is operationally simple. The catalyst and the reaction byproduct can be removed easily by filtration. Using this method, a fluorine atom can be introduced to the tertiary position of 1,4-cineole and L-menthone selectively.

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Figures

Fig. 1
Fig. 1
Development of vanadium-catalyzed oxidative C–H functionalization reactions
Fig. 2
Fig. 2
KIE study of the vanadium-catalyzed C–H fluorination
See this image and copyright information in PMC

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