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. 1989 Mar;27(3):391-5.
doi: 10.1111/j.1365-2125.1989.tb05383.x.

Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects

N Brion  1 , E Naline, D Beaumont, M Pays, C Advenier
Affiliations

Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects

N Brion et al. Br J Clin Pharmacol. 1989 Mar.

Abstract

The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half-lives, areas under the plasma concentration-time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.

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