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Review
. 2014 Aug;25(4):304-8.
doi: 10.1097/MOL.0000000000000092.

Apolipoprotein A-I mimetics

Srinivasa T Reddy  1 , Mohamad Navab, Gattadahalli M Anantharamaiah, Alan M Fogelman
Affiliations
Review

Apolipoprotein A-I mimetics

Srinivasa T Reddy et al. Curr Opin Lipidol. 2014 Aug.

Abstract

Purpose of review: To summarize recent publications in the field of apolipoprotein mimetics.

Recent findings: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as potential therapeutic agents. A number of new apolipoprotein mimetics have been described recently. A major site of action of apolipoprotein mimetic peptides was found to be in the small intestine in which they decrease the levels of proinflammatory bioactive lipids. A major problem related to the use of apolipoprotein mimetic peptides is their cost, particularly those that need to be generated by solid phase synthesis with chemical addition of end-blocking groups. Novel approaches to apolipoprotein mimetic therapy have emerged recently that show promise in overcoming these barriers.

Summary: Despite the recent failure of therapies designed to raise HDL-cholesterol in humans, an approach to therapy using mimetics of HDL and its components continues to show promise.

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References

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