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Review
. 2014 Aug;25(4):282-8.
doi: 10.1097/MOL.0000000000000094.

microRNA regulation of lipoprotein metabolism

Leigh Goedeke  1 , Juan F Aranda, Carlos Fernández-Hernando
Affiliations
Review

microRNA regulation of lipoprotein metabolism

Leigh Goedeke et al. Curr Opin Lipidol. 2014 Aug.

Abstract

Purpose of review: The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels.

Recent findings: In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1.

Summary: The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.

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Conflict of interest statement

CONFLICTC OF INTEREST

There are no conflicts of interest.

Figures

Figure 1
Figure 1. miRNAs that regulate LDL metabolism
The figure represents the initiator, miRNA target genes and the overall effect of miRNAs that control LDL metabolism. ? indicates unknown initiator or miRNA target gene.
Figure 2
Figure 2. miRNAs that regulate HDL metabolism
The figure represents the initiator, miRNA target genes and the overall effect of miRNAs that control HDL metabolism.
See this image and copyright information in PMC

References

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