Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov;127(11):1128-1131.
doi: 10.1016/j.amjmed.2014.06.016. Epub 2014 Jun 27.

Use of sirolimus in the treatment of refractory autoimmune hepatitis

Hemant Chatrath  1 , Larissa Allen  1 , Thomas D Boyer  2
Affiliations

Use of sirolimus in the treatment of refractory autoimmune hepatitis

Hemant Chatrath et al. Am J Med. 2014 Nov.

Abstract

Background: Corticosteroids and azathioprine are widely accepted as the initial therapy for autoimmune hepatitis. However, the disease is refractory to steroids in about 10%-20% of patients, for whom currently there is no standardized treatment. Here we describe our experience with sirolimus in treatment of steroid refractory autoimmune hepatitis.

Methods: This is a longitudinal follow-up study. Between November 2007 and January 2014, 5 subjects with steroid refractory autoimmune hepatitis were treated with sirolimus at our institution.

Results: A response, defined as a sustained >50% fall in alanine aminotransferase (ALT) levels, was achieved in 4/5 patients. A complete response, sustained normalization of ALT levels, was achieved in 2/5 patients. The need for steroids was significantly reduced in all patients (P < .05).

Conclusions: In this small series, sirolimus appears to be useful in the treatment of patients with steroid refractory autoimmune hepatitis.

Keywords: Autoimmune hepatitis; Sirolimus; Steroid-refractory.

PubMed Disclaimer

LinkOut - more resources