Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jun 30;211(7):1271.
doi: 10.1084/jem.2117insight1.

Identification of a severe bleeding disorder in humans caused by a mutation in CalDAG-GEFI

William A Muller  1
Affiliations
Comment

Identification of a severe bleeding disorder in humans caused by a mutation in CalDAG-GEFI

William A Muller. J Exp Med. .
No abstract available

PubMed Disclaimer

Figures

None
Insight from William Muller
None
Adhesion of calcein-AM–labeled platelets to fibrillar collagen under flow (750 s-1) from a homozygous (HOM), heterozygous (HET), and healthy (Ctl) subject. Percentage of covered area was assessed over 300 seconds (left). The initial 60 seconds are magnified (right).
See this image and copyright information in PMC

Comment on

  • Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.
    Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, Germain M, Raslova H, Peiretti F, Morange PE, Saut N, Pillois X, Nurden AT, Cambien F, Pierres A, van den Berg TK, Kuijpers TW, Alessi MC, Tregouet DA. Canault M, et al. J Exp Med. 2014 Jun 30;211(7):1349-62. doi: 10.1084/jem.20130477. Epub 2014 Jun 23. J Exp Med. 2014. PMID: 24958846 Free PMC article. Clinical Trial.

References

    1. Canault M., et al. . 2014. J. Exp. Med. 10.1084/jem.20130477. - DOI - PubMed

Substances