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. 1989 Mar;8(3):823-9.
doi: 10.1002/j.1460-2075.1989.tb03443.x.

The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein

A M Nunez  1 , M Berry, J L Imler, P Chambon
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The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein

A M Nunez et al. EMBO J. 1989 Mar.

Abstract

Expression of the pS2 gene which is transcriptionally controlled by oestrogens in the breast cancer cell line MCF-7 is oestrogen independent in stomach mucosa. We show here that the level of MCF-7 cell pS2 mRNA can also be increased by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). We further demonstrate, using transient transfection assays, that the -428 to -332 5' flanking sequence of the pS2 gene contains DNA enhancer elements responsive to oestrogens, TPA, EGF, the c-Ha-ras oncoprotein and the c-jun protein.

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References

    1. Nature. 1988 Mar 17;332(6161):275-8 - PubMed
    1. Science. 1988 Mar 18;239(4846):1400-5 - PubMed
    1. Biochem Biophys Res Commun. 1988 Feb 29;151(1):306-13 - PubMed
    1. Nucleic Acids Res. 1988 Mar 25;16(5):1903-19 - PubMed
    1. Science. 1988 Apr 22;240(4851):524-6 - PubMed

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