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. 2004 Oct;1(2):171-7.
doi: 10.1016/j.ddtec.2004.09.007.

From genes to drugs: target validation in Caenorhabditis elegans

Ann E Sluder  1 , Ralf Baumeister  2
Affiliations

From genes to drugs: target validation in Caenorhabditis elegans

Ann E Sluder et al. Drug Discov Today Technol. 2004 Oct.

Abstract

A central challenge in post-genomic drug discovery is selection of relevant therapeutic targets from a large pool of candidates, so that resources are invested productively. Key to meeting this challenge is demonstrating target function in disease-related pathways in vivo. The nematode Caenorhabditis elegans, a well-characterized experimental system for genetic analysis of biological regulatory pathways, provides a powerful means of assessing the impact of modulating target function on biological processes, thus facilitating selection of high-value targets.:

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