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. 2004 Dec;1(3):217-24.
doi: 10.1016/j.ddtec.2004.10.009.

Scaffold hopping

Hans-Joachim Böhm  1 , Alexander Flohr  1 , Martin Stahl  2
Affiliations

Scaffold hopping

Hans-Joachim Böhm et al. Drug Discov Today Technol. 2004 Dec.

Abstract

The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article. Their application has led to several molecules with chemically completely different core structures, and yet binding to the same receptor. Computational approaches for scaffold hopping highlight the challenges of the field that are still unsolved.:

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