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. 2005 Summer;2(2):155-61.
doi: 10.1016/j.ddtec.2005.05.002.

Accelerating lead development by microwave-enhanced medicinal chemistry

William D Shipe  1 , Scott E Wolkenberg  1 , Craig W Lindsley  2
Affiliations

Accelerating lead development by microwave-enhanced medicinal chemistry

William D Shipe et al. Drug Discov Today Technol. 2005 Summer.

Abstract

Microwave-assisted organic synthesis (MAOS) addresses the need for accelerated chemical synthesis by providing many advantages over classical thermal conditions. Microwave instruments produced by Biotage, CEM and Milestone enable chemistry to be safely and reproducibly performed on various scales and in a parallel fashion. To illustrate the high utility of this technology for lead development, our Akt kinase program will be described wherein MAOS played a pivotal role in the identification of isozyme-selective Akt inhibitors.:

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