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. 1989 Feb;80(2):107-10.
doi: 10.1111/j.1349-7006.1989.tb02275.x.

Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-beta

M Mukai  1 , K Shinkai, K Komatsu, H Akedo
Affiliations

Potentiation of invasive capacity of rat ascites hepatoma cells by transforming growth factor-beta

M Mukai et al. Jpn J Cancer Res. 1989 Feb.

Abstract

The in vitro invasive capacity of poorly invasive cells (W1), which were cloned from rat ascites hepatoma cells (AH 130), was potentiated dose- and time-dependently by pretreating the cells with transforming growth factor-beta (TGF-beta). This potentiation of invasive capacity was completely abolished by anti-TGF-beta antibody. When the treated cells were ip inoculated into rats, the cells extensively invaded the peritoneum, and formed penetrating tumor nodules. The effect of TGF-beta was reversed by subculturing the treated cells without TGF-beta. The potentiation of invasive capacity by TGF-beta might participate in platelet-associated enhancement of tumor cell metastasis.

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References

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