Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Feb;80(2):111-4.
doi: 10.1111/j.1349-7006.1989.tb02276.x.

The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects

K Miki  1 , M Ichinose, N Kawamura, M Matsushima, H B Ahmad, M Kimura, J Sano, T Tashiro, N Kakei, H Oka, et al.
Affiliations

The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects

K Miki et al. Jpn J Cancer Res. 1989 Feb.

Abstract

Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer-free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non-invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer.

PubMed Disclaimer

References

    1. ) Samloff , I. M.Pepsinogens, pepsins and pepsin inhibitors . Gastroenterology , 60 , 586 – 604 ( 1971. ). - PubMed
    1. ) Hirschowitz , B. I.Pepsinogen: its origin, secretion and excretion , Physiol. Rev. , 37 , 475 – 511 ( 1957. ). - PubMed
    1. ) Bock , O. A. A. , Arapakis , G. , Witts , L. J. and Richards , C. D.The serum pepsiongen level with special reference to the histology of the gastric mucosa . Gut , 4 , 106 – 111 ( 1963. ). - PMC - PubMed
    1. ) Mirsky , I. A. , Futterman , P. and Kaplan , S.Blood plasma pepsinogen II. The activity of plasma from normal subjects, patients with duodenal ulcer and patients with pernicious anemia . J. Lab. Clin. Med. , 40 , 188 – 199 ( 1952. ). - PubMed
    1. ) Samloff , I. M. , Secrist , D. M. and Passaro , E. J.A study of the relationship between serum group I pepsinogen levels and gastric acid secretion . Gastroenterology , 69 , 1196 – 1200 ( 1975. ). - PubMed

LinkOut - more resources