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Case Reports
. 2014 Jul;27(3):235-8.
doi: 10.1080/08998280.2014.11929123.

Adult T-cell leukemia/lymphoma

Robbie L Graham  1 , Micah Burch  1 , John R Krause  1
Affiliations
Case Reports

Adult T-cell leukemia/lymphoma

Robbie L Graham et al. Proc (Bayl Univ Med Cent). 2014 Jul.

Abstract

Adult T-cell leukemia/lymphoma is a rare malignancy associated with the human retrovirus human T-cell lymphotropic virus type 1. It is characterized by the proliferation of highly pleomorphic lymphocytes. Involvement of peripheral blood, bone marrow, lymph nodes, spleen, and extranodal sites such as skin, liver, gastrointestinal tract, and central nervous system can occur. There are four distinct clinical variants, and the prognosis and clinical course range from highly aggressive to a more protracted course depending on the subtype. We describe a man with de novo adult T-cell leukemia/lymphoma and discuss the unique clinical, morphologic, immunophenotypic, and molecular features of this entity.

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Figures

Figure.
Figure.
Morphology of adult T-cell leukemia/lymphoma with abundant polylobated “flower cells.” Peripheral blood stained with Wright's stain (original magnification under oil 1000×).
See this image and copyright information in PMC

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