Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;67(1):43-8.
doi: 10.5173/ceju.2014.01.art9. Epub 2014 Apr 17.

Effectiveness of combined high-dosed trospium and solifenacin depending on severity of OAB symptoms in elderly men and women under cyclic therapy

Kirill Kosilov  1 , Sergey Loparev  2 , Marina Iwanowskaya  3 , Liliya Kosilova  4
Affiliations

Effectiveness of combined high-dosed trospium and solifenacin depending on severity of OAB symptoms in elderly men and women under cyclic therapy

Kirill Kosilov et al. Cent European J Urol. 2014.

Abstract

Material and methods: 313 patients, 196 women and 117 men over 65 (average age 68.6) were included in this study. All patients underwent urodynamic examination before enrollment and after the study was completed. For clinical evaluation of LUT state ICIQ-SF questionnaires and bladder diaries were used. Patients with moderate (А, n = 155) and severe (В, n = 158) symptoms of OAB. Each group was divided into subgroups in which patients received Trospium 60 mg/day and Solifenacin 20 mg/day during two cycles - 1.5 and 1 month with one month interval (А1 and В1); subgroups in which second cycle was substituted with placebo (А2, В2), and control groups (А3, В3).

Results: In groups with moderate symptoms of OAB ratio of patients demonstrated decrease of frequency of EI ≥1.5 a day remained at the level of 45-60% during all observation period. In subgroups with severe symptoms of OAB percentage of such patients was 55.3% for the subgroup which received two cycle therapy, and decreased to 26% in the subgroup which underwent 1 cycle therapy. Urodynamic indices for state of LUT correlated with clinical indicators (r =0.57-0.71 at p≤ 0.05).

Conclusions: Short single cycle of high-dosed Solifenacin and Trospium in elderly patients with moderate symptoms of OAB enables to maintain long therapeutic effect with acceptable level of side effects. This treatment algorithm applied in two cycle course is an effective and safe method for management of severe symptoms of OAB in elderly patients without increased risk of side effects.

Keywords: antimuscarinic; elderly; overactive bladder.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Algorithm of examination and treatment of elderly patients with varying baseline symptom severity.
Figure 2
Figure 2
Impact of solifenacin and trospium on urinary incontinence episodes per day over time in patients with OAB according to baseline symptom severity.
Figure 3
Figure 3
Effectiveness of solifenacin and trospium on urinary urgency episodes per day over time in patients with OAB according to baseline symptom severity.
Figure 4
Figure 4
Ratio of patient overtime a reduction over 1.5 incontinence episodes per day according to baseline symptom severity.
See this image and copyright information in PMC

References

    1. Milsom I, Coyne KS, Nicholson S, Kvasz M, Chen CI, Wein AJ. Global Prevalence and Economic Burden of Urgency Urinary Incontinence: A Systematic Review. Eur Urol. 2013;65:79–95. - PubMed
    1. Ruffion A, Castro–Diaz D, Patel H, Khalaf K, Onyenwenyi A, Globe D, et al. Systematic review of the epidemiology of urinary incontinence and detrusor overactivity among patients with neurogenic overactive bladder. Neuroepidemiology. 2013;41:146–155. - PubMed
    1. Milsom I, Stewart W, Thuroff J. The prevalence of overactive bladder. Am J Manag Care. 2000;6(Suppl):S565–573. - PubMed
    1. Heesakkers JP, Cruz F, Igawa Y, Kocjancic E. Overactive bladder: pathophysiology, diagnostics, and therapies. Adv Urol. 2011;2011:863504. - PMC - PubMed
    1. Rantell A. Assessment and diagnosis of overactive bladder in women. Nurs Stand. 2013;27:35–40. - PubMed

LinkOut - more resources