Roles of renal proximal tubule transport in acid/base balance and blood pressure regulation

Abstract

Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na(+)-HCO3 (-) cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium transport in PTs also plays an important role in the regulation of blood pressure. For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance. Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis. Paradoxically, the effects of Ang II on PT transport are known to be biphasic. Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. In this paper, we will review the physiological and pathophysiological roles of PT transport.

Figure 1

Ang II signaling in mouse and human PTs. In mouse PTs, low concentrations of Ang II induce transport stimulation via either PKC activation or decrease in intracellular cAMP resulting in ERK activation, while high concentrations of Ang II induce transport inhibition via NO/cGMP/cGKII pathway. In human PTs, by contrast, Ang II induces dose-dependent transport stimulation via NO/cGMP/ERK pathway.