Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jul 18;16(14):3688-91.
doi: 10.1021/ol5014747. Epub 2014 Jul 1.

A free-radical cascade trifluoromethylation/cyclization of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate and iodine pentoxide

Lizhi Zhang  1 , Zejiang Li, Zhong-Quan Liu
Affiliations

A free-radical cascade trifluoromethylation/cyclization of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate and iodine pentoxide

Lizhi Zhang et al. Org Lett. .

Abstract

An I(2)O(5)-promoted free-radical cascade trifluoromethylation/cyclization of a broad range of N-arylmethacrylamides and enynes with sodium trifluoromethanesulfinate in aqueous medium has been achieved. This strategy allows highly selective access to a variety of CF(3)-containing oxindoles and pyrrolidines. Electron spin resonance (ESR) studies indicate that atom-transfer processes are involved in this system.

PubMed Disclaimer

Publication types

LinkOut - more resources