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. 2014 Jul 28;20(31):9534-8.
doi: 10.1002/chem.201402893. Epub 2014 Jul 1.

Palladium-catalyzed carbonylative α-arylation to β-ketonitriles

Johannes Schranck  1 , Mia Burhardt, Christoph Bornschein, Helfried Neumann, Troels Skrydstrup, Matthias Beller
Affiliations

Palladium-catalyzed carbonylative α-arylation to β-ketonitriles

Johannes Schranck et al. Chemistry. .

Abstract

A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient (13) C-labelling of the generated carbonyl moiety.

Keywords: carbonylation; palladium; α-arylation; β-ketonitriles.

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