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. 2014 May;10(5):287-93.

Hepatitis C virus infection and its rheumatologic implications

Zeynel A Sayiner  1 , Uzma Haque  1 , Mohammad U Malik  1 , Ahmet Gurakar  1
Affiliations

Hepatitis C virus infection and its rheumatologic implications

Zeynel A Sayiner et al. Gastroenterol Hepatol (N Y). 2014 May.

Abstract

Extrahepatic manifestations are frequently encountered among patients with chronic hepatitis C virus (HCV) infection. Many of these manifestations are autoimmune disorders, with added mortality and morbidity due to involvement of multiple organ systems. Symptoms of HCV infection and rheumatic diseases may be similar and include arthralgia, myalgia, arthritis, and vasculitis. Also, serologic abnormalities may be found in both cases. Some treatment modalities for HCV infection, including interferon therapy, may aggravate the symptoms of rheumatic diseases, thus confounding clinical presentation. It is imperative to distinguish whether symptoms such as arthralgia, myalgia, and arthritis occur in patients with HCV infection due to primary chronic HCV infection or to a newly developed rheumatologic disease process.

Keywords: Hepatitis C virus; autoimmune disease; rheumatologic implication.

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Figures

Figure
Figure
The relationship between HCV infection and rheumatologic diseases. HCV, hepatitis C virus; MC, mixed cryoglobulinemia; PAN, polyarteri-tis nodosa; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus.
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