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Case Reports
. 2014:158:A7179.

[Venous thrombosis as a first sign of SLE]

[Article in Dutch]
Suzanne M Pronk  1 , C Heleen van Ommen, Femke H M Prince, Olivier Weijer, Marion A J van Rossum
Affiliations
  • PMID: 24988153
Case Reports

[Venous thrombosis as a first sign of SLE]

[Article in Dutch]
Suzanne M Pronk et al. Ned Tijdschr Geneeskd. 2014.

Abstract

Background: Venous thrombosis in children is rare. In adolescents it may be the first manifestation of a chronic disease such as systemic lupus erythematosus (SLE).

Case description: An obese 12-year-old girl visited the Obesity Clinic and mentioned pain in her right calf. Some time before her arrival she spent time in bed with a respiratory infection. Deep vein thrombosis was diagnosed by ultrasonography. Radiography showed an infiltrate, laboratory tests showed elevated inflammatory parameters, and thrombophilia testing showed a Factor V Leiden mutation as well as the presence of lupus anticoagulants. During her stay she developed haematological, immunological and clinical signs of SLE.

Conclusion: The cause of venous thrombosis in children is usually multifactorial. Despite the presence of obvious risk factors, it is important to follow adolescents with thrombosis and to be alert for any signs of an underlying systemic disease.

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