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Comment
. 2014 Jul 1;107(1):8-9.
doi: 10.1016/j.bpj.2014.05.021.

Don't flip out: AChRs are primed to catch and hold your attention

Andrew J R Plested  1
Affiliations
Comment

Don't flip out: AChRs are primed to catch and hold your attention

Andrew J R Plested. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
The grammar of nicotinic receptor gating. A receptor with two binding sites, like the muscle nicotinic receptor, with possible congeners of the flip, prime, catch, and hold reactions around the extracellular binding sites. All reactions are potentially independent from the opening of the channel (bottom row, green membrane domain). All binding sites are initially in the resting configuration, ready to “catch” agonist. Within the context of this model incorporating the catch-and-hold idea, “Priming” may follow or initiate binding site transformation into the “hold” configuration. Likewise, the phenomenon described as “Flip” might represent a concerted jump from the first to the third row. Opacity indicates rough probability of occurrence, illustrating why linear schemes still approximate the data well. Outer arrows indicate cycle of equilibrium constants used to calculate high-affinity binding. To see this figure in color, go online.
See this image and copyright information in PMC

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References

    1. Langley J.N. On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J. Physiol. 1905;33:374–413. - PMC - PubMed
    1. Neher E., Sakmann B. Single-channel currents recorded from membrane of denervated frog muscle fibers. Nature. 1976;260:799–802. - PubMed
    1. Purohit P., Bruhova I., Auerbach A. Catch and hold activation of muscle acetylcholine receptors having transmitter binding site mutations. Biophys. J. 2014;107:88–99. - PMC - PubMed
    1. Jadey S.V., Purohit P., Auerbach A. Design and control of acetylcholine receptor conformational change. Proc. Natl. Acad. Sci. USA. 2011;108:4328–4333. - PMC - PubMed
    1. Purohit P., Auerbach A. Unliganded gating of acetylcholine receptor channels. Proc. Natl. Acad. Sci. USA. 2009;106:115–120. - PMC - PubMed

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