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Comment
. 2014 Jul 1;20(1):8-9.
doi: 10.1016/j.cmet.2014.06.013.

Mitobolites: the elixir of life

Subhash D Katewa  1 , Amit Khanna  1 , Pankaj Kapahi  2
Affiliations
Comment

Mitobolites: the elixir of life

Subhash D Katewa et al. Cell Metab. .

Abstract

One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.

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Figures

Figure 1
Figure 1. The role of mitochondria-derived metabolites, ‘mitobolites’, in modulating metabolism, growth and longevity
Interventions that modulate mitochondrial functions regulate the flux of mitobolites. Mitobolites (red dots) potentially regulate mitochondrial proteins, including mitochondrial ATPase (black structures), and once released from mitochondria, these mitobolites may also regulate cellular signaling pathways. This in turn modulates various physiological processes like metabolism, growth and longevity.
See this image and copyright information in PMC

Comment on

  • The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
    Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. Chin RM, et al. Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. Nature. 2014. PMID: 24828042 Free PMC article.

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