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. 2014 Jul 1;20(1):192-192.e1.
doi: 10.1016/j.cmet.2014.06.001.

SnapShot: sirtuins, NAD, and aging

Takashi Nakagawa  1 , Leonard Guarente  2
Affiliations
Free article

SnapShot: sirtuins, NAD, and aging

Takashi Nakagawa et al. Cell Metab. .
Free article

Abstract

Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.

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