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Review
. 2014;37(7):1081-9.
doi: 10.1248/bpb.b14-00265.

Physiological functions and underlying mechanisms of fibroblast growth factor (FGF) family members: recent findings and implications for their pharmacological application

Toru Imamura  1
Affiliations
Free article
Review

Physiological functions and underlying mechanisms of fibroblast growth factor (FGF) family members: recent findings and implications for their pharmacological application

Toru Imamura. Biol Pharm Bull. 2014.
Free article

Abstract

Despite their name, fibroblast growth factors (FGFs) are multifunctional regulators affecting a wide variety of physiological events. This review summarizes our recent studies on FGFs from mechanistic, physiological and application-oriented viewpoints. These include studies on the importance of βKlotho and glycosaminoglycans for the signaling of hormonal FGFs (FGF21 and FGF19); the physiological role of a paracrine FGF (FGF18) in hair cycle regulation; and the development of a stable, chimeric FGF protein composed of FGF1 and FGF2 domains suitable for radioprotection.

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