Editorial
doi: 10.1038/ajg.2014.179.
The IBD drug pipeline-ready to deliver?
Affiliations
- PMID: 24989095
- DOI: 10.1038/ajg.2014.179
Item in Clipboard
Editorial
The IBD drug pipeline-ready to deliver?
Am J Gastroenterol.
2014 Jul.
Abstract
The study of modified-release phosphatidylcholine in this issue of the American Journal of Gastroenterology by Karner et al. is a substantial step forward for a mucosal barrier agent in inflammatory bowel disease (IBD). It is the first agent in a novel class to demonstrate clinical efficacy in a phase 2 study. There are a number of new agents with new mechanisms of action that are rapidly advancing through the IBD drug development pipeline. This article reviews the promising candidates and mechanisms of action in late-phase trials in IBD.
Comment on
-
First multicenter study of modified release phosphatidylcholine "LT-02" in ulcerative colitis: a randomized, placebo-controlled trial in mesalazine-refractory courses.Am J Gastroenterol. 2014 Jul;109(7):1041-51. doi: 10.1038/ajg.2014.104. Epub 2014 May 6. Am J Gastroenterol. 2014. PMID: 24796768 Free PMC article. Clinical Trial.
Similar articles
-
Exploring the Phosphatidylcholine in Inflammatory Bowel Disease: Potential Mechanisms and Therapeutic Interventions.Curr Pharm Des. 2022;28(43):3486-3491. doi: 10.2174/1381612829666221124112803. Curr Pharm Des. 2022. PMID: 36424797 Review.
-
Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis.Gut. 2005 Jul;54(7):966-71. doi: 10.1136/gut.2004.052316. Gut. 2005. PMID: 15951544 Free PMC article. Clinical Trial.
-
Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Subcommittee on Immunosuppressive Use of the Pediatric IBD Collaborative Research Forum.Am J Gastroenterol. 1993 Jan;88(1):44-8. Am J Gastroenterol. 1993. PMID: 8420272
-
[Mucosal protection by phosphatidylcholine as new therapeutic concept in ulcerative colitis].Z Gastroenterol. 2013 Apr;51(4):384-9. doi: 10.1055/s-0033-1335042. Epub 2013 Apr 12. Z Gastroenterol. 2013. PMID: 23585269 Review. German.
-
Health-related quality of life correlates with clinical and endoscopic activity indexes but not with demographic features in patients with ulcerative colitis.Inflamm Bowel Dis. 2006 Nov;12(11):1058-67. doi: 10.1097/01.mib.0000234134.35713.d2. Inflamm Bowel Dis. 2006. PMID: 17075347 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
