This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Editorial

. 2014 Jul 7;115(2):208-10.

doi: 10.1161/CIRCRESAHA.114.304383.

Two strikes and you're out: gene-gene mutation interactions in HCM

Gerald W Dorn 2nd¹, Elizabeth M McNally¹

Affiliations

Affiliation

¹ From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and Institute for Cardiovascular Research, Department of Medicine, The University of Chicago, IL (E.M.M.). emcnally@medicine.bsd.uchicago.edu gdorn@dom.wustl.edu.

PMID: 24989488
PMCID: PMC4083473
DOI: 10.1161/CIRCRESAHA.114.304383

Editorial

Two strikes and you're out: gene-gene mutation interactions in HCM

Gerald W Dorn 2nd et al. Circ Res. 2014.

. 2014 Jul 7;115(2):208-10.

doi: 10.1161/CIRCRESAHA.114.304383.

Authors

Gerald W Dorn 2nd¹, Elizabeth M McNally¹

Affiliation

¹ From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and Institute for Cardiovascular Research, Department of Medicine, The University of Chicago, IL (E.M.M.). emcnally@medicine.bsd.uchicago.edu gdorn@dom.wustl.edu.

PMID: 24989488
PMCID: PMC4083473
DOI: 10.1161/CIRCRESAHA.114.304383

No abstract available

Keywords: Editorials; genetics; models, animal.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1. Schematic depiction of variable genetic and non-genetic influences on individual phenotype
Left, different forms of secondary mutations. Right, role of secondary mutations in context of other modifying influences.

See this image and copyright information in PMC

Comment on

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.
Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP. Blankenburg R, et al. Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14. Circ Res. 2014. PMID: 24829265 Free PMC article.

Similar articles

β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.
Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman CE, Lohse MJ, Schmitt JP. Blankenburg R, et al. Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14. Circ Res. 2014. PMID: 24829265 Free PMC article.
Gene symbol: MYH7.
Iascone MR, Marchetti D, Ferrazzi P. Iascone MR, et al. Hum Genet. 2007 Feb;120(6):915. Hum Genet. 2007. PMID: 17438618 No abstract available.
Gene symbol: MYH7.
Iascone MR, Marchetti D, Ferrazzi P. Iascone MR, et al. Hum Genet. 2007 Feb;120(6):916. Hum Genet. 2007. PMID: 17438619 No abstract available.
Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives.
Maron BJ, Maron MS, Semsarian C. Maron BJ, et al. J Am Coll Cardiol. 2012 Aug 21;60(8):705-15. doi: 10.1016/j.jacc.2012.02.068. Epub 2012 Jul 11. J Am Coll Cardiol. 2012. PMID: 22796258 Review.
Functional consequences of mutations in the myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
Lowey S. Lowey S. Trends Cardiovasc Med. 2002 Nov;12(8):348-54. doi: 10.1016/s1050-1738(02)00181-0. Trends Cardiovasc Med. 2002. PMID: 12536121 Review.

See all similar articles

Cited by

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.
Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S. Barefield D, et al. J Mol Cell Cardiol. 2015 Feb;79:234-43. doi: 10.1016/j.yjmcc.2014.11.018. Epub 2014 Nov 25. J Mol Cell Cardiol. 2015. PMID: 25463273 Free PMC article.
MYH7 in cardiomyopathy and skeletal muscle myopathy.
Gao Y, Peng L, Zhao C. Gao Y, et al. Mol Cell Biochem. 2024 Feb;479(2):393-417. doi: 10.1007/s11010-023-04735-x. Epub 2023 Apr 20. Mol Cell Biochem. 2024. PMID: 37079208 Review.
Dilated Cardiomyopathy: A Genetic Journey from Past to Future.
Newman NA, Burke MA. Newman NA, et al. Int J Mol Sci. 2024 Oct 25;25(21):11460. doi: 10.3390/ijms252111460. Int J Mol Sci. 2024. PMID: 39519012 Free PMC article. Review.
Genetic Testing in Patients with Hypertrophic Cardiomyopathy.
Bonaventura J, Polakova E, Vejtasova V, Veselka J. Bonaventura J, et al. Int J Mol Sci. 2021 Sep 27;22(19):10401. doi: 10.3390/ijms221910401. Int J Mol Sci. 2021. PMID: 34638741 Free PMC article. Review.
Genetic advances in sarcomeric cardiomyopathies: state of the art.
Ho CY, Charron P, Richard P, Girolami F, Van Spaendonck-Zwarts KY, Pinto Y. Ho CY, et al. Cardiovasc Res. 2015 Apr 1;105(4):397-408. doi: 10.1093/cvr/cvv025. Epub 2015 Jan 29. Cardiovasc Res. 2015. PMID: 25634555 Free PMC article. Review.

See all "Cited by" articles

References

1. Mendel G. Versuche über Pflanzen-Hybriden. Verh. Naturforsch. Ver. Brünn. 1866;4:3–47.
1. Lanktree MB, Guo Y, Murtaza M, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011;88:6–18. - PMC - PubMed
1. Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. 1990;62:999–1006. - PubMed
1. Blankenburg R, Hackert K, Wurster S, Deenen R, Seidman JG, Seidman C, Lohse MJ, Schmitt JP. beta-Myosin Heavy Chain Variant Met606Val Causes Very Mild Hypertrophic Cardiomyopathy in Mice, but Exacerbates HCM Phenotypes in Mice Carrying Other HCM Mutations. Circ Res. 2014 - PMC - PubMed
1. Lupski JR, Belmont JW, Boerwinkle E, Gibbs RA. Clan genomics and the complex architecture of human disease. Cell. 2011;147:32–43. - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Molecular Biology Databases
- Mouse Genome Informatics (MGI)