Two strikes and you're out: gene-gene mutation interactions in HCM
- PMID: 24989488
- PMCID: PMC4083473
- DOI: 10.1161/CIRCRESAHA.114.304383
Two strikes and you're out: gene-gene mutation interactions in HCM
Keywords: Editorials; genetics; models, animal.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
Comment on
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β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.Circ Res. 2014 Jul 7;115(2):227-37. doi: 10.1161/CIRCRESAHA.115.303178. Epub 2014 May 14. Circ Res. 2014. PMID: 24829265 Free PMC article.
References
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- Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. 1990;62:999–1006. - PubMed
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