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Multicenter Study
. 2014 Jul 2:14:673.
doi: 10.1186/1471-2458-14-673.

Maternal education, anthropometric markers of malnutrition and cognitive function (ELSA-Brasil)

Larissa Fortunato Araújo  1 , Luana Giatti, Dora Chor, Valéria Maria Azeredo Passos, Sandhi Maria Barreto
Affiliations
Multicenter Study

Maternal education, anthropometric markers of malnutrition and cognitive function (ELSA-Brasil)

Larissa Fortunato Araújo et al. BMC Public Health. .

Abstract

Background: The early exposure to poor social and nutritional conditions may influence cognitive function during adult age. However, the relative impact of these factors has not yet been established and they can vary during the course of life.

Methods: Analysis of data from 12,997 participants (35-64 years) of the baseline exams (2008-2010) of the Longitudinal Study of Adult Health (ELSA-Brasil), a cohort of Brazilian civil servants. Four cognitive tests were applied: learning, recall and word recognition; semantic and phonemic verbal fluency; trail-making test version B. The markers of early nutritional and social conditions were maternal educational level, birth weight, and length of trunk and leg. The presence of independent association between every early marker and the poor performance in each cognitive test was investigated by multiple logistic regression, after mutual adjustment and considering the effects of gender, age and participant's schooling level. The cut off for poor performance was the worst age-specific percentile of the final score distribution for each test.

Results: After full adjustments, lower maternal education increased the chances of poor performance in all cognitive tests, with a dose-response gradient; low birth-weight was related to poor performance in the trail-making test B (OR = 1.63, 95% IC = 1.29-2.06); and greater trunk length decreased the chances of poor performance in the semantic and phonemic verbal fluency (OR = 0.96, 95% IC = 0.94-0.97) and in the trail-making test B (OR = 0.94, 95% IC = 0.92-0.95). Leg length was not associated with any of the tests examined. The associations found were not modified by the educational attainment of the participants.

Conclusions: Early exposure to adverse social and nutritional conditions appear detrimental to semantic memory, learning, concentration, executive control and language among adults, independent of adulthood educational achievement.

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References

    1. Sliwinski MJ, Hofer SM, Hall C, Buschke H, Lipton RB. Modelling memory decline in older adults: the importance of preclinical dementia, attrition, and chronological age. Psychol Aging. 2003;18:658–671. - PubMed
    1. Steinerman JR, Hall CB, Sliwinski MJ, Lipton RB. Modelling cognitive trajectories within longitudinal studies: a focus on older adults. J Am Geriatr Soc. 2010;58(2):313–318. - PMC - PubMed
    1. Hackman DA, Farah MJ, Meaney MJ. Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat Rev Neurosci. 2010;11(9):651–659. - PMC - PubMed
    1. Singh-Manoux A, Richards M, Marmot M. Socioeconomic position across the life course: how does it relate to cognitive function in mid-life? Ann Epidemiol. 2005;15:572–578. - PubMed
    1. Hazzouri AZ, Haan MN, Galea S, Aiello AE. Life-Course Exposure to Early Socioeconomic Environment, Education in Relation to Late-Life Cognitive Function Among Older Mexicans and Mexican Americans. J Aging Health. 2011;23(7):1027–1049. - PMC - PubMed

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