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Comment
. 2014 Jul 1;28(13):1381-3.
doi: 10.1101/gad.246462.114.

LINEing germ and embryonic stem cells' silencing of retrotransposons

Takashi Ishiuchi  1 , Maria-Elena Torres-Padilla  1
Affiliations
Comment

LINEing germ and embryonic stem cells' silencing of retrotransposons

Takashi Ishiuchi et al. Genes Dev. .

Abstract

Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410-1428) and Castro-Diaz and colleagues (pp. 1397-1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals.

Keywords: DNA methylation; KAP1; LINE1; evolution; piRNA; transposon.

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References

    1. Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ 2007. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316: 744–747 - PubMed
    1. Brouha B, Schustak J, Badge RM, Lutz-Prigge S, Farley AH, Moran JV, Kazazian HH Jr 2003. Hot L1s account for the bulk of retrotransposition in the human population. Proc Natl Acad Sci 100: 5280–5285 - PMC - PubMed
    1. Carmel MA, Girad A, van de Kant HJ, Bourch’his D, Bestor TH, de Rooij DG, Hannon GJ 2007. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell 12: 503–514 - PubMed
    1. Castro-Diaz N, Ecco G, Coluccio A, Kapopoulou A, Yazdanpanah B, Friedli M, Duc J, Jang SM, Turelli P, Trono D 2014. Evolutionally dynamic L1 regulation in embryonic stem cells. Genes Dev (this issue). doi: 10.1101/gad.241661.114 - PMC - PubMed
    1. Cordaux R, Batzer MA 2009. The impact of retrotransposons on human genome evolution. Nat Rev Genet 10: 691–703 - PMC - PubMed

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