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. 2014 Apr 25;48(2):197-202.
doi: 10.2478/raon-2013-0077. eCollection 2014 Jun.

Xp 11.2 translocation renal carcinoma in young adults; recently classified distinct subtype

Andrej Kmetec  1 , Jera Jeruc  2
Affiliations

Xp 11.2 translocation renal carcinoma in young adults; recently classified distinct subtype

Andrej Kmetec et al. Radiol Oncol. .

Abstract

Background: XP11.2 renal translocation carcinomas are often encountered in paediatric group of patients where they are believed to be rather indolent. They are rare but more aggressive in young adults. They are slow growing, sometimes without characteristic symptoms and their biologic behaviour is uncertain.

Case report: We report two cases of this type of tumour in Slovenian young adult males with long and unusual history. Tumours were confirmed imunohistologically by positive reaction for CD10, P504S and TFE3.

Conclusions: According to the indications in the literature prognosis of these tumours in young adults depends upon the stage. It seems that cysts, haematomas and necrosis around the kidney are often encountered in these tumours. In advanced stage with lymph nodes involvement or distant metastases, the prognosis is poor. Surgery seems to be basic mode of therapy.

Keywords: histology; renal tumours; translocation renal cell carcinoma.

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Figures

FIGURES 1, 2.
FIGURES 1, 2.
Abdominal CT scan of 27 year adult male.
FIGURES 1, 2.
FIGURES 1, 2.
Abdominal CT scan of 27 year adult male.
FIGURE 3, 4.
FIGURE 3, 4.
CT scan of the 31 year adult male with cystic mass.
FIGURE 3, 4.
FIGURE 3, 4.
CT scan of the 31 year adult male with cystic mass.
FIGURE 5.
FIGURE 5.
Translocation renal cell carcinoma composed of clear cells with voluminous cytoplasm and distinct cell borders showing typical papillary architecture and hyalinised fibrovascular cords.
FIGURE 6.
FIGURE 6.
Translocation renal cell carcinoma composed of clear cells arranged in tubule-alveolar pattern laying in hyalinised stroma. There are some psammoma bodies in the lower right corner.
FIGURE 7.
FIGURE 7.
Strong diffuse nuclear transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3) immunostaining.
See this image and copyright information in PMC

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